The aim of the Wainger Laboratory is to ask clinically relevant research questions that could lead to rapid translation and innovation for treating diseases of the motor and sensory nervous systems.
We employ stem cell-based modeling, primary human tissue and mouse models. We use patch-clamp, extracellular multi-electrode array recording, calcium imaging as well as molecular and genetic tools to obtain insight into disease mechanisms that we can then use to translate into potential new clinical therapies. We believe that in vitro interrogation of disease-relevant stem cell-derived neurons is a gateway to personalized medicine and individualized treatments.
We are part of the MassGeneral Institute for Neurodegenerative Diseases, Harvard Stem Cell Institute, Broad Institute, and the Harvard Program in Neuroscience.