Dr. Wainger is Assistant Professor Neurology and Anesthesiology at Harvard Medical School and an attending physician at Massachusetts General Hospital. He studied molecular biology as an undergraduate at Princeton University and ion channel physiology in the MD/PhD program at Columbia University. He then completed medical residency in the Partners Neurology Program followed by a clinical fellowship in Pain Medicine at MGH and research fellowship with Clifford Woolf at Boston Children’s Hospital. His clinical expertise spans the intersection of neurology and pain medicine.
Joao Pereira, PhD
After completing a PhD in the Epigenetics of Neural Development in the Livesey lab, at the University of Cambridge, and a first post-doctoral position at Brigham and Women's Hospital/Harvard Medical School, Joao headed to the Wainger lab to focus on the neurobiology and pathology of ALS.
Dan Dubreuil, PhD
Dan received his undergraduate degree in Biochemistry and Molecular Biology from Otterbein University and his Ph.D. in Neuroscience from Brown University. For his doctoral work, Dan worked in the lab of Dr. Diane Lipscombe and studied the contribution of voltage-gated calcium channels to nociceptor function, inflammatory pain, and pain-related behaviors in mice.
Dan joined the Wainger lab in January 2018 with a primary interest in using human neurons to understand the cellular and molecular mechanisms that lead to chronic pain.
Paloma Gonzalez-Perez, MD, PhD
Paloma’s clinical and research interests are motor neuron disease and myopathies. She recently joined the Neurology Department at MGH as faculty. She spends her time in clinic taking care of patients with neuromuscular diseases and in Dr. Wainger's lab investigating the effect of mutated VCP in in vitro hiPSC-derived skeletal and motor neuron cell models.
Christine Marques, PhD
After graduating with a degree in biotechnology engineering at Polytech Marseille, Christine completed her PhD in Neuroscience under the mentorship of Dr. Caroline Rouaux (INSERM U1118) at the University of Strasbourg. During her PhD, Christine deciphered the molecular mechanisms that selectively trigger CSMN dysfunction and degeneration during the course of ALS and improved characterization of the cortical pathology in this disease. She developed a protocol that allowed, for the first time, the transcriptomic analyses of pure populations of CSMN isolated from the cerebral cortex of adult wild type and Sod1G86R mice at different stages of the disease.
In July 2018, Christine joined the Wainger lab, where she is interested in applying stem cell biology to better understand the cellular and molecular mechanisms of protein spread involved in ALS.
Aaron Held, PhD
Aaron completed his BA and MA degrees at Boston University and his Ph.D at Brown University with Dr. Kristi Wharton and Dr. Diane Lipscombe. His graduate work found a contribution of non-motor neurons to motor circuit dysfunction in a Drosophila model of ALS, and identified BMP signaling as a modifier of neurodegeneration in the same model. Aaron joined the Wainger lab in December 2018 and is interested in using hiPSCs to study altered neuronal activity in ALS.
Eugene joined the Wainger Laboratory as a research technician in 2016. He has a BS in Neuroscience at Johns Hopkins University and specializes in data analysis. He has written software to track cell bodies longitudinally, trace neurites, visualize high-dimensional electrophysiology data, and create probabilistic network maps from in vitro calcium imaging.
Kevin joined Dr. Wainger's lab as a research assistant in July 2017. He received a BS degree in both Cellular & Molecular Biology and Economics from the University of Michigan. He is interested in investigating the health of iPSC-derived motor neurons from control and ALS patients and their response to various drugs in a high-throughput manner. Recently, he has studied inflammatory pain in mouse dorsal root ganglia and trigeminal ganglia through calcium imaging. Kevin will be attending medical school next fall.
Patrick joined the Wainger Lab as a research assistant in June 2018 after graduating from Johns Hopkins University with a BS in Neuroscience. In the field of pain research, he is interested in the molecular mechanisms of pain sensitivity. He is also generally interested in neuronal energy metabolism, especially as it relates to ALS.
James joined the Wainger Lab as a research assistant in 2018. He received his undergraduate degree in Human Evolutionary Biology from Harvard University. He is interested in better understanding neurodevelopmental and neurodegenerative disorders using in vitro models.
Visiting Research Assistant
Sophie joined the Wainger lab to write a review on iPSC use in ALS through her master’s program 'Molecular Neuroscience' at the University of Amsterdam. She holds a BS degree in neuro-genetics and is specifically interested in looking at current issues in ALS modeling from a genetic perspective.
Abel is a medical student following a Medicine/Research double curriculum in Tours, France. He joined the Wainger lab in early 2019 as part of his master’s program “Integrated Cellular Neuroscience” at Sorbonne University, Paris. Under the supervision of Christine Marques, he is working on in vitro models in order to study prion-like mechanisms involved in ALS pathophysiology.